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The Halogenation of Some Benzamides Takes Place Preferentially at the ortho, para Positions
Author(s) -
Dong ChangZhi,
Julia Marc,
Tang Jie
Publication year - 1998
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/(sici)1099-0690(199808)1998:8<1689::aid-ejoc1689>3.0.co;2-m
Subject(s) - chemistry , halogenation , organic chemistry , stereochemistry , medicinal chemistry
The orientation of chlorination and bromination of N, N ‐disubstituted benzamides in aqueous acetic acid is strongly influenced by the nature of the alkyl groups at the nitrogen atom. With large groups, the halogenation takes place fairly selectively at the ortho / para positions.