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New Triquinane‐Type Sesquiterpenoids from Macrocystidia cucumis (Basidiomycetes)
Author(s) -
Hellwig Veronika,
Dasenbrock Johannes,
Schumann Susanne,
Steglich Wolfgang,
Leonhardt Klaus,
Anke Timm
Publication year - 1998
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/(sici)1099-0690(199801)1998:1<73::aid-ejoc73>3.0.co;2-f
Subject(s) - chemistry , stereochemistry , cucumis , absolute configuration , mycelium , botany , biology
Arthrosporone ( 1 ) and eight new triquinane‐type sesquiterpenoids have been isolated from mycelial cultures of the agaric Macrocystidia cucumis. The cucumins A−D ( 2 , 4 − 6 ) are highly unsaturated hirsutane derivatives, whereas the cucumins E−G ( 7 − 9 ) represent a new type of linear triquinanes. Cucumin H ( 10 ) is a new member of the ceratopicane group. The absolute configuration of cucumin F ( 8 ) was assigned by 1 H‐NMR analysis of the corresponding Mosher esters. Two further metabolites were identified as cyclo (phenylalanylprolyl) ( 12 ) and cyclo (leucylprolyl) ( 13 ). Cucumin A ( 2 ) exhibits antibacterial and cytotoxic activities.