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Calcium Ions Do Accelerate the DNA Binding of New Antitumor‐Active Platinum Aminophosphonate Complexes
Author(s) -
Bloemink Marieke J.,
Diederen Jeroen J. H.,
Dorenbos Jaco P.,
Heetebrij Robert J.,
Keppler Bernhard K.,
Reedijk Jan
Publication year - 1999
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/(sici)1099-0682(199910)1999:10<1655::aid-ejic1655>3.0.co;2-5
Subject(s) - chemistry , phosphonate , chelation , platinum , ligand (biochemistry) , calcium , stereochemistry , dna , kinetics , ion , medicinal chemistry , inorganic chemistry , organic chemistry , biochemistry , catalysis , receptor , physics , quantum mechanics
The presence of Ca 2+ has a marked effect on the reaction kinetics of platinum phosphonate complexes with d(GpG). Compounds studied are [ cis ‐Pt(NH 3 ) 2 (bmpaa)] and [Pt( R , S ‐dach)(ntmp)]. The formation of GG‐ N7,N7 chelates and the release of the phosphonate ligand as observed by NMR is significantly accelerated by the presence of Ca 2+ , which is ascribed to its interaction with the phosphato groups in the ligands.