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Synthesis, Structural Characteristics and Biological Activities of Complexes of Zn II , Cd II , Hg II , Pd II , and Pt II with 2‐Acetylpyridine 4‐Methylthiosemicarbazone
Author(s) -
Bermejo Elena,
Carballo Rosa,
Castiñeiras Alfonso,
Domínguez Ricardo,
Liberta Anthony E.,
MaichleMössmer Cäcilia,
Salberg Michelle M.,
West Douglas X.
Publication year - 1999
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/(sici)1099-0682(199906)1999:6<965::aid-ejic965>3.0.co;2-a
Subject(s) - chemistry , zinc , pyridine , nuclear magnetic resonance spectroscopy , medicinal chemistry , halide , semicarbazone , metal , stereochemistry , ligand (biochemistry) , inorganic chemistry , organic chemistry , biochemistry , receptor
Reaction of 2‐acetylpyridine 4‐methylthiosemicarbazone (H4ML) with halides of zinc(II), cadmium(II), and mercury(II) afforded complexes of the form [M(H4ML)X 2 ] [M = Zn II ( 1 – 3 ), Cd II ( 4 – 6 ) or Hg II ( 7 – 9 ); × = Cl, Br, or I]. Reaction of H4ML with K 2 PdCl 4 and K 2 PtCl 4 gave compounds of the form [M(4ML)Cl] [M = Pd II ( 10 ) or Pt II ( 11 )]. In all the new compounds, which were characterized by elemental analyses, conductance measurements, and electronic, IR and 1 H‐ and 13 C‐NMR spectroscopy, and by 113 Cd‐, 195 Pt‐, or 199 Hg‐NMR spectroscopy when relevant, the ligand is N,N,S‐tridentate, coordinating to the metal centre through its pyridine and azomethine nitrogen atoms and its thiocarbonyl sulfur atom, as was confirmed by X‐ray diffraction studies in the cases of 4 · 2 DMSO, 5 · 2 DMSO, 6 · 2 DMSO, 7 · 2 DMSO, 10 , and 11 . In in‐vitro assays, only [Zn(H4ML)Cl 2 ] and [Zn(H4ML)Br 2 ] showed some sign of antifungal activity against Aspergillus niger or Paecilomyces variotii .