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Bis(dipeptide ester–H + ) Complexes of Palladium(II) – Precursors for the Formation of Cyclotetrapeptides
Author(s) -
Haas Katharina,
EhrenstorferSchäfers EvaMaria,
Polborn Kurt,
Beck Wolfgang
Publication year - 1999
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/(sici)1099-0682(199903)1999:3<465::aid-ejic465>3.0.co;2-5
Subject(s) - dipeptide , chemistry , palladium , deprotonation , amide , sodium methoxide , stereochemistry , peptide , medicinal chemistry , catalysis , organic chemistry , biochemistry , ion
trans ‐Bis(dipeptide ester)palladium 1 – 6 complexes with a deprotonated amide group were obtained by dehydrochlorination of trans ‐Cl 2 Pd(dipeptide ester) 2 or by direct reaction of Na 2 PdCl 4 with dipeptide ester in the presence of sodium methoxide. The structure of Pd(NH 2 CH 2 CONCH 2 CH 2 CO 2 CH 3 ) 2 ( 3 ) was determined by X‐ray diffraction. Addition of NaOCH 3 to Pd[NH 2 C(H)(R)NCH 2 CH 2 CO 2 CH 3 ] 2 [R = CH(CH 3 ) 2 4 , CH 2 Ph 5 ] results in the formation of the corresponding complexes 7 , 8 with cyclic tetrapeptides which also can be directly synthesized from the dipeptide ester and Na 2 PdCl 4 .