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17 O‐NMR, EPR and NMRD Characterization of [Gd(DTPA‐BMEA)(H 2 O)]: A Neutral MRI Contrast Agent
Author(s) -
Tóth Éva,
Connac Fabienne,
Helm Lothar,
Adzamli Kofi,
Merbach André E.
Publication year - 1998
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/(sici)1099-0682(199812)1998:12<2017::aid-ejic2017>3.0.co;2-z
Subject(s) - electron paramagnetic resonance , chemistry , molecule , gadolinium , ligand (biochemistry) , crystallography , rotational correlation time , nuclear magnetic resonance , nitroxide mediated radical polymerization , polymerization , organic chemistry , polymer , biochemistry , physics , receptor , radical polymerization
A study including variable‐temperature and ‐pressure, multiple‐field 17 O NMR, EPR and NMRD has been performed on the MRI contrast agent, [Gd(DTPA‐BMEA)(H 2 O)]. The water exchange rate [ k ex 298 = (0.39 ± 0.02) × 10 6 s −1 ] and the activation volume (Δ V ≠ = +7.4 ± 0.4 cm 3 mol −1 ), hence the mechanism, are identical to those for [Gd(DTPA‐BMA)(H 2 O)]. The longer rotational correlation time of [Gd(DTPA‐BMEA)(H 2 O)], as obtained from a global analysis of 17 O‐NMR, EPR and NMRD data, and compared to that of [Gd(DTPA‐BMA)(H 2 O)], can be explained by water molecules hydrogen‐bonded to the ether oxygen atoms of the ligand side chain.