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A Pulse Radiolysis Study of an Imidazolato‐Bridged Asymmetric Dicopper(II) Complex: A Structural and Functional Mimic of Superoxide Dismutase
Author(s) -
Tabbì Giovanni,
Nauser Thomas,
Koppenol Willem H.,
Reedijk Jan
Publication year - 1998
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/(sici)1099-0682(199812)1998:12<1939::aid-ejic1939>3.0.co;2-4
Subject(s) - chemistry , radiolysis , superoxide dismutase , superoxide , reaction rate constant , kinetics , ligand (biochemistry) , reactivity (psychology) , enzyme , photochemistry , stereochemistry , radical , biochemistry , receptor , medicine , physics , alternative medicine , pathology , quantum mechanics
The ability of a dicopper(II) complex with a pentadentate, imidazolato‐bridged ligand having two different coordination environments to mimic the reactivity of superoxide dismutase has been investigated by pulse radiolysis. Pseudo first‐order kinetics were observed for superoxide scavenging, with a very high rate constant of 1.9 ± 0.4 × 10 9 M −1 s −1 , consistent with catalytic dismutation of superoxide by the complex. This value is essentially constant over the pH range of 5 to 7, and agrees with earlier results obtained with the nitroblue tetrazolium assay.