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Metal Complexes of Alkyne‐Bridged α‐Amino Acids
Author(s) -
Kayser Bernd,
Altman Janina,
Nöth Heinrich,
Knizek Jörg,
Beck Wolfgang
Publication year - 1998
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/(sici)1099-0682(199811)1998:11<1791::aid-ejic1791>3.0.co;2-h
Subject(s) - chemistry , alkyne , hexa , ferrocene , benzene , cationic polymerization , tetra , medicinal chemistry , metal , ligand (biochemistry) , chelation , palladium , stereochemistry , polymer chemistry , organic chemistry , electrochemistry , catalysis , receptor , biochemistry , electrode
The palladium‐mediated coupling of p ‐ethynylphenylalanine ( p ‐epa) with different halogenated benzenes yielded alkyne‐bridged α‐amino acids. A series of cationic mono‐ to hexanuclear (Ph 3 P) 2 Pt complexes with the anions of p ‐ethynylphenylalanine and alkynyl‐ or benzene‐bridged di‐, tri‐, tetra‐ and hexa‐ethynyl phenylalanines as N,O‐chelate ligands was prepared. N ‐ t ‐Boc‐ p ‐ethynylphenylalanine methyl ester was metal‐substituted to give complexes of the types Ph 3 PAu‐C≡C–R and (Et 3 P) 2 Pt(C≡CR) 2 . The benzene‐bridged di‐, tri‐, tetra‐ and hexa‐ p ‐ethynylphenylalanine methyl esters form Schiff bases with ferrocene aldehyde and a tripodal ligand was obtained from Ph 2 PCH 2 CH 2 CH 2 NH 2 and the benzene‐bridged tri‐ethynylphenylalanine. The structure of (Ph 3 P) 2 Pt[NH 2 C(H)(CH 2 C 6 H 4 C≡CH)CO 2 ] + BF 4 − was determined by X‐ray diffraction.