Premium
Towards New Iron(III) Chelators: Synthesis and Complexing Ability of a Water‐Soluble Tripodal Ligand Based on 2,2′‐Dihydroxybiphenyl Subunits
Author(s) -
Baret Paul,
Beaujolais Virginie,
Béguin Claude,
Gaude Didier,
Pierre JeanLouis,
Serratrice Guy
Publication year - 1998
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/(sici)1099-0682(199805)1998:5<613::aid-ejic613>3.0.co;2-l
Subject(s) - chemistry , deprotonation , ligand (biochemistry) , denticity , chelation , amide , tripodal ligand , biphenyl , stereochemistry , combinatorial chemistry , medicinal chemistry , metal , organic chemistry , ion , biochemistry , receptor
Abstract A new water‐soluble iron(III) sequestering agent has been designed. The tris‐bidentate tripodal ligand consists of three 2,2′‐dihydroxybiphenyl subunits connected via amide linkages at their meta (4‐) positions to a framework of the “tren” type. The key step of the synthesis involves the coupling of suitably substituted monophenyl moieties in order to obtain the biphenyl precursor. The deprotonation constants of the ligand, and the formation and deprotonation constants of the Fe III complex have been determined from potentiometric and spectrophotometric measurements. The results are compared with those of a previously described homologous ligand in which the chelating subunits are attached to the tren framework via the ortho (3‐) position of the biphenyl rather than the 4‐position.