Premium
Nickel‐Catalysed 1,4‐Addition of Aryl Groups to Enones Using Aryldialkylaluminum Compounds
Author(s) -
Westermann Jürgen,
Imbery Ute,
Nguyen Anh Thu,
Nickisch Klaus
Publication year - 1998
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/(sici)1099-0682(199802)1998:2<295::aid-ejic295>3.0.co;2-9
Subject(s) - transmetalation , chemistry , aryl , nickel , reagent , halide , catalysis , conjugate , organic chemistry , combinatorial chemistry , medicinal chemistry , alkyl , mathematical analysis , mathematics
The transmetallation of arylmagnesium halides or aryllithium with Me 2 AlCl results in the formation of aryldimethylaluminum compounds. These arylaluminum compounds are useful reagents for conjugate additions to enones in the presence of Ni(acac) 2 as a catalyst. 3‐Aryl ketones are obtained in good yields in these catalytic reactions. Starting from the 3‐oxo‐Δ 1,4 ‐steroids this method gives access to 1α‐arylsteroids.