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Improvement of disseminated lymphangiomatosis with recombinant interferon therapy
Author(s) -
Laverdière Caroline,
David Michèle,
Dubois Josée,
Russo Pierre,
Hershon Linda,
Lapierre JeanGuy
Publication year - 2000
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/(sici)1099-0496(200004)29:4<321::aid-ppul13>3.0.co;2-c
Subject(s) - lymphangiomatosis , medicine , lung , alpha interferon , spleen , pathology , interferon alfa , interferon , immunology , lymphatic system
Disseminated lymphangiomatosis is a rare disorder with a poor prognosis. We present a case involving a 3‐year‐old boy who presented with pulmonary infiltrates, multiple lytic lesions of the ribcage, and small cystic lesions in the spleen. Open‐lung and bone biopsies revealed disseminated lymphangiomatosis. Significant clinical and radiologic improvement were observed and persisted after 28 months of treatment with recombinant interferon alpha‐2b (IFN alpha‐2b). No significant toxicity has been observed. Pediatr Pulmonol. 2000;29:321–324. © 2000 Wiley‐Liss, Inc.