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Pulmonary function, serum markers of inflammation, and IgG antibodies to core lipopolysaccharide of Burkholderia cepacia in adults with cystic fibrosis, following colonization with Burkholderia cepacia
Author(s) -
Hendry J.,
Nixon L.,
Dodd M.,
Elborn J.S.,
Govan J.,
Shale D.J.,
Webb A.K.
Publication year - 2000
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/(sici)1099-0496(200001)29:1<8::aid-ppul2>3.0.co;2-s
Subject(s) - cystic fibrosis , medicine , sputum , burkholderia , pseudomonas aeruginosa , immunology , antibody , respiratory disease , inflammation , gastroenterology , lung , pathology , bacteria , biology , tuberculosis , genetics
Eight patients with cystic fibrosis [CF] colonized with Pseudomonas aeruginosa ( P. aeruginosa ) had serial lung function, peripheral blood inflammatory markers, and serum IgG antibodies to Burkholderia cepacia ( B. cepacia ) lipopolysaccharide measured in the months preceding and following colonisation with B. cepacia . One patient experienced a fall in FEV 1 from 33% to 19% of predicted values, coinciding with the first sputum isolation of B. cepacia , and he died 12 weeks later. He had a rise in inflammatory markers preterminally, and this change was refractory to antibiotic therapy. There was no significant fall in FEV 1 % of predicted values in the remaining seven patients, and no significant changes in their serum markers of inflammation following colonization with B. cepacia over a median (range) period of 10.9 (7.3–12.0) months. Pediatr Pulmonol. 2000; 29:8–10. © 2000 Wiley‐Liss, Inc.