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Pulmonary function at school‐age in surfactant‐treated preterm infants
Author(s) -
Gappa Monika,
Berner Michael M.,
Hohenschild Stephan,
Dammann Christiane E.L.,
Bartmann Peter
Publication year - 1999
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/(sici)1099-0496(199903)27:3<191::aid-ppul7>3.0.co;2-z
Subject(s) - medicine , respiratory distress , functional residual capacity , pulmonary function testing , lung volumes , placebo , pulmonary surfactant , surfactant therapy , airway resistance , prospective cohort study , bronchopulmonary dysplasia , lung , pediatrics , gastroenterology , anesthesia , gestational age , pregnancy , pathology , physics , alternative medicine , genetics , biology , thermodynamics
A follow‐up study was conducted in 40 children who had been enrolled in a prospective randomized study of exogenous surfactant therapy for respiratory distress syndrome (RDS) (n = 22; S) or placebo (n = 18; P) to determine long‐term pulmonary sequelae of surfactant treatment in premature infants with RDS. At follow‐up, mean (SD) age was 6.63 (0.18) and 6.55 (0.23) years for S and P, respectively. Complete lung function tests (LFT) were attempted in all patients. Satisfactory data were obtained in 17/22 surfactant‐treated and in 12/18 control children. There was no significant difference between groups for any of the parameters measured. Mean (SD) functional residual capacity (FRC) was 92% (16%) and 90% (21%) predicted, mean (SD) airway resistance (R aw,exp ) was 122% (25%) and 127% (61%), and mean (SD) forced expiratory volume in 1 s (FEV 1 ) was 104% (12%) and 99% (17%) predicted for S and P. Only maximal expiratory flow at 25% vital capacity (L/s) was significantly below the predicted range in S and P groups, with 74% (23%) and 77% (28%), respectively. To test bronchial hyperreactivity, a simple standardized running test was performed: 4 children in S and 5 in P showed a significant response as defined by clinical airway obstruction or changes in FEV 1 and/or R aw , with no significant difference between groups. Although we found no major abnormalities in lung function and no difference between S and P at early school‐age, lack of cooperation during lung function tests makes further follow‐up necessary. Pediatr Pulmonol. 1999; 27:191–198. © 1999 Wiley‐Liss, Inc.