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Inspiratory flow limitation in children with bronchopulmonary dysplasia
Author(s) -
Sadeghi Hossein,
Lowenthal Diana B.,
Dozor Allen J.
Publication year - 1998
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/(sici)1099-0496(199809)26:3<167::aid-ppul3>3.0.co;2-i
Subject(s) - medicine , bronchopulmonary dysplasia , pulmonary function testing , vital capacity , air trapping , asthma , airway obstruction , bronchodilator , airway , cardiology , pediatrics , anesthesia , lung function , lung , diffusing capacity , gestational age , pregnancy , genetics , biology
The objective of this study was to compare pulmonary function tests of children with bronchopulmonary dysplasia (BPD) and asthma, and to evaluate children with BPD for evidence of upper airway obstruction. This is a case‐control retrospective study of pulmonary function tests (PFTs) of 11 children with BPD between 5 and 8 years of age who were followed by pediatric pulmonologists, and of 32 age‐ and height‐matched children with asthma. The median forced vital capacity (FVC), forced expiratory volume in one second (FEV 1 ), and peak expiratory flow (PEF) were significantly lower in the BPD group (0.86 L, 0.79 L, 120 L/min) than in the asthmatic group (1.34 L, 1.21 L, 155 L/min; P = 0.002, P = 0.007, P = 0.004, respectively). Both groups were equally hyperinflated (median thoracic gas volume 155% of predicted values in the BPD compared to 152% predicted in the asthma group; P = 0.67), and both groups showed decreases in air‐trapping after a bronchodilator. The ratios of forced expiratory flow at 50% of the FVC to forced inspiratory flow at 50% of the FVC (FEF 50% /FIF 50% ) and FEV 1 to PEF (FEV 1 /PEF) were used to assess upper airway obstruction and were higher in children with BPD than asthma ( P = 0.0001 and P = 0.035, respectively). We conclude that pulmonary function of children with BPD who are still symptomatic after 5 years of age is different from age‐matched children with asthma, and the children with BPD demonstrate significant inspiratory flow limitations. Pediatr Pulmonol. 1998;26:167–172. © 1998 Wiley‐Liss, Inc.