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Lung mechanics in infants with left‐to‐right shunt congenital heart disease
Author(s) -
Yau KuoInn,
Fang LiJung,
Wu MeiHwan
Publication year - 1996
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/(sici)1099-0496(199601)21:1<42::aid-ppul7>3.0.co;2-s
Subject(s) - medicine , right to left shunt , shunt (medical) , lung disease , cardiology , lung , heart disease , hypoplastic left heart syndrome , respiratory physiology , pediatrics , intensive care medicine , patent foramen ovale , migraine
To clarify which hemodynamic measurement correlates best with lung mechanics in infants with congenital heart disease and left‐to‐right shunts, dynamic pulmonary function tests and echocardiography were performed in 26 infants with such disease (study infants) and in 37 normal, healthy infants (control infants). The tidal volume and pulmonary compliance (C L ) were lower and airway resistance higher in infants with congenital heart disease than in control infants. A significant correlation was demonstrated between C L , expiratory resistance (R e ), and the right pulmonary artery‐to‐aortic size ratio (RPA/DAO). C L and R e also correlated well with the corrected acceleration time √RR ratio (ACT/√RR: ACT, acceleration time and RR: length of the cardiac cycle) of pulmonary flow velocity. Stepwise multiple regression analysis revealed that RPA/DAO correlated best with both C L and R e . It is concluded that infants with congenital heart disease and left‐to‐right shunts have lower lung compliance and higher expiratory airway resistance than normal children, and that RPA/DAO is the echocardiographic parameter that correlates best with the changes in lung mechanics. Pediatr Pulmonol. 1996; 21:42–47. © 1996 Wiley‐Liss, Inc.