Open AccessFlow cytometric findings in the floral variant of follicular lymphoma
Author(s) -
Dunphy Cherie H.,
Wolaniuk Janusz W.,
Turgeon Ronald P.
Publication year - 1998
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/(sici)1098-2825(1998)12:5<310::aid-jcla11>3.0.co;2-y
Subject(s) - follicular lymphoma , follicular phase , biology , lymphoma , immunology , genetics
The floral variant of follicular lymphoma (FL‐F) is an unusual variant of follicular lymphoma. The malignant “follicles” have an unusual “floral” appearance due to the proliferation of surrounding and infiltrating small lymphocytes. This variant of malignant lymphoma has been supported by immunohistochemical immunophenotyping and gene‐rearrangement studies; however, the flow cytometric findings have not previously been described. We report the flow cytometric findings in two cases of FL‐F. The surrounding and infiltrating small lymphocytes represented mantle cells which, in one case, obscured monoclonality were CD10+, supporting a follicular center cell origin. J. Clin. Lab. Anal. 12:310–314, 1998. © 1998 Wiley‐Liss, Inc.