Open AccessPrognostic significance of cell cycle parameters in infiltrative ductal breast carcinoma
Author(s) -
Užarević B.,
Petrovečki M.,
Marušić M.,
JakićRazumović J.,
Hutinec Z.,
Sabioncello A.,
Gamulin S.
Publication year - 1998
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/(sici)1098-2825(1998)12:3<131::aid-jcla1>3.0.co;2-c
Subject(s) - lymph node , medicine , aneuploidy , pathology , ductal carcinoma , carcinoma , lymph , oncology , cell cycle , mammary gland , axillary lymph nodes , flow cytometry , stage (stratigraphy) , breast cancer , biology , cancer , chromosome , immunology , biochemistry , gene , paleontology
Flow‐cytometric DNA analysis was performed retrospectively from paraffin‐embedded blocks in 158 consecutive ductal infiltrative breast carcinoma patients grades I–III. Normal breast tissue was used as control. Tumor proliferative activity, cell ploidy, and DNA index (DI) were related to age of patients, histological grade of tumor, tumor size, axillary lymph node status, estrogen and progesterone receptor status, menopausal status, TNM clinical classification, and survival. There was a significant association between DNA aneuploidy and a high cellular proliferative activity, increased DI, poor differentiation of tumor, primary tumor size, number of positive lymph nodes, and postmenopausal state. Increased proportion of cells in S‐phase was associated with positive lymph node status and higher number of positive lymph nodes. The cell cycle parameters had no prognostic value either for overall survival of disease‐free survival of the patients. J. Clin. Lab. Anal. 12:131–136, 1998. © 1998 Wiley‐Liss, Inc.