Open AccessNew molecular diagnostic tests for two congenital forms of anemia
Author(s) -
Auerbach Arleen D.,
Verlander Peter C.,
Brown Kevin E.,
Liu Johnson M.
Publication year - 1997
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/(sici)1098-2825(1997)11:1<17::aid-jcla4>3.0.co;2-h
Subject(s) - anemia , medicine , pediatrics
Congenital hypoplastic anemias are a rare and heterogeneous group of disorders. This paper reviews new molecular diagnostic tests in two distinct forms of congenital anemias, anemia due to transplacental infection with B19 parvovirus and Fanconi anemia. In both instances, molecular assays making use of amplification of DNA by the polymerase chain reaction have been used to diagnose either a specific viral infection or gene mutation responsible for a disorder. Recognition of these entities has important prognostic and therapeutic implications. J. Clin. Lab. Anal. 11:17–22. © 1997 Wiley‐Liss, Inc.