Open AccessNasal mucosal cells in human immunodeficiency virus type 1‐seropositive patients with sinusitis
Author(s) -
Moss Ronald B.,
Scott Thomas A.,
Goldrich Michael,
Pitale Michelle,
Daniel Anne,
Lebovics Robert,
Walker Robert,
Igarashi Yasu,
Kaliner Michael A.
Publication year - 1996
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/(sici)1098-2825(1996)10:6<418::aid-jcla18>3.0.co;2-#
Subject(s) - sinusitis , mucous membrane of nose , medicine , immunology , chronic sinusitis , population , mucous membrane , immune system , pathology , environmental health
Recently, sinusitis has been recognized as a frequent clinical problem in human immunodeficiency virus (HIV‐1)‐infected individuals. We hypothesized that quantitative defects in immune cells in the nasal mucosa of HIV‐positive subjects might mirror those in the peripheral blood and explain a predisposition to sinus disease in this population. Nasal mucosa biopsies were obtained from three different groups of patients—HIV‐1 seropositive with sinusitis, HIV‐1 seronegative with sinusitis, and HIV‐1 seronegative without sinusitis (normal volunteer)—and phenotyped for cluster of differentiation antigen (CD) markers. In this study, we found patients with HIV‐1 and sinus disease to have significantly lower numbers of both CD3 and CD4 nasal mucosa lymphocytes than seronegative controls in the nasal mucosa ( P <0.05, P <0.01, respectively). A correlation between nasal mucosal CD4 cells and peripheral‐blood CD4 cells was noted (R = 0.67, P ≤ 0.01). No deficiency in the number of nasal mucosa T or TC type mast cells was noted for the HIV‐1‐positive sinusitis group. Further study is warranted to define more completely the pathophysiology and microbiology of, and therapy for, this important clinical problem. © 1996 Wiley‐Liss, Inc.