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Intracellular and intercellular transport of many germ cell mRNAs is mediated by the DNA‐ and RNA‐binding protein, testis‐brain‐RNA‐binding protein (TB‐RBP)
Author(s) -
Hecht Norman B.
Publication year - 2000
Publication title -
molecular reproduction and development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 105
eISSN - 1098-2795
pISSN - 1040-452X
DOI - 10.1002/(sici)1098-2795(200006)56:2+<252::aid-mrd8>3.0.co;2-8
Subject(s) - biology , microbiology and biotechnology , rna , cytoplasm , rna binding protein , intracellular , cell nucleus , genetics , gene
Functions ranging from RNA transport and translational regulation to DNA rearrangement and repair have been proposed for the DNA‐ and RNA‐binding protein, testis‐brain‐RNA‐binding protein (TB‐RBP). TB‐RBP is primarily in the nuclei of male germ cells during meiosis and in the cytoplasm of male cells after metaphase I of meiosis. Based on its shift in subcellular locations as germ cells differentiate and its binding to microtubules and microfilaments, a model is presented proposing an involvement of TB‐RBP in mRNA transport from nucleus to cytoplasm and in the sharing of mRNAs transcribed from the sex chromosomes by movement through intercellular bridges of germ cells. Mol. Reprod. Dev. 56:252–253, 2000. © 2000 Wiley‐Liss, Inc.