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The gas‐phase basicities and proton affinities of amino acids and peptides
Author(s) -
Harrison Alex. G.
Publication year - 1997
Publication title -
mass spectrometry reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 126
eISSN - 1098-2787
pISSN - 0277-7037
DOI - 10.1002/(sici)1098-2787(1997)16:4<201::aid-mas3>3.0.co;2-l
Subject(s) - chemistry , affinities , gas phase , proton affinity , proton , amino acid , molecule , computational chemistry , stereochemistry , organic chemistry , protonation , biochemistry , ion , physics , quantum mechanics
The methods of establishing gas‐phase basicities and proton affinities are reviewed, particularly as applied to thermally labile and involatile molecules. The literature on the basicities of amino acids is critically reviewed, and a consistent set of gas‐phase basicities for α‐amino acids is recommended. The problems associated with deriving proton affinities from these data are discussed. The literature on the gas‐phase basicities of peptides is reviewed, and inconsistencies in the experimental results are discussed. © 1998 John Wiley & Sons, Inc., Mass Spectrom Rev 16, 201–217, 1997