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Establishment of a parabiotic rat model by anastomosis of common carotid artery
Author(s) -
Rikihisa Naoaki,
Saito Seiko,
Ichinose Masaharu,
Yano Akihiko
Publication year - 2000
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/(sici)1098-2752(2000)20:3<116::aid-micr4>3.0.co;2-u
Subject(s) - medicine , parabiosis , anastomosis , tropism , carotid arteries , blood circulation , surgery , common carotid artery , right common carotid artery , artery , immunology , virus , traditional medicine
A cross circulation model was established by replacing mutual blood between two rats by anastomoses of each common carotid artery. In this model, parabiotic rats were shown to replace their mutual blood completely without any artificial materials or instruments, such as silicon tubes or pumps. The rate of blood exchange was measured by intravenous injection of Evans blue dye without the use of the radioactive materials that were so far commonly used. The partial alteration of blood circulation through microvascular surgery may reveal the mechanisms of organ tropism of bacteria, protozoa, and parasites. Microvascular surgery is available for reconstruction and analysis of organ functions as well as for clinical use in organplasty. © 2000 Wiley‐Liss, Inc. MICROSURGERY 20:116–120 2000