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Prolongation of rat heart allograft survival with K + ATP‐dependent channel modulators
Author(s) -
Rheaume Dominic,
Dumont Louis,
Peng Junzheng,
Xu Dasheng,
Qi Shijie,
Liu Dingyi,
Chen Huifang
Publication year - 1999
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/(sici)1098-2752(1999)19:7<314::aid-micr4>3.0.co;2-w
Subject(s) - glibenclamide , medicine , activator (genetics) , gliclazide , pharmacology , potassium channel , endocrinology , receptor , diabetes mellitus
Controversies exist regarding the immunoregulatory properties of K + ATP channel modulators. We investigated the effects of aprikalim, a K + ATP‐dependent channels activator, and glibenclamide and gliclazide, two inhibitors of K + ATP‐dependent channels, on the prolongation of heart allograft survival in the rat. Nine groups (n ≥ 5) were involved in this study with the Brown‐Norway to Lewis rat combination treated with aprikalim, glibenclamide, gliclazide, and/or cyclosporine. The results indicate that modulators of K + ATP‐dependent channels can improve the survival of rat heart allograft without interfering with the immunosuppressive properties of cyclosporine. © 1999 Wiley‐Liss, Inc. MICROSURGERY 19:314–317 1999