Premium
A new rat model to study the correlation of cardiac and skeletal muscle allograft rejection
Author(s) -
Blanchard Jacqueline,
Massad Malek,
Sekosan Marin,
Dunn Ty,
Raofi Vandad,
Holman Dawn,
Ramasastry Sai,
Lutrin Frank,
Benedetti Enrico
Publication year - 1998
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/(sici)1098-2752(1998)18:7<406::aid-micr3>3.0.co;2-2
Subject(s) - medicine , correlation , skeletal muscle , cardiology , cardiac muscle , mathematics , geometry
As a first step to study the correlation of cardiac and skeletal muscle allograft rejection, we describe a new experimental rat model of simultaneous heterotopic heart and cutaneous maximus muscle flap allotransplant. Brown Norway rats were used as donors and Lewis rats as recipients. No immunosuppression was given. The grafts were revascularized with sequential end‐to‐side anastomosis of each vascular pedicle to the infrarenal aorta and vena cava. Syngeneic heart and cutaneous maximus muscle grafts remained functional and showed no sign of rejection at 7 days after the transplant. In contrast, both allografts developed severe rejection and functional compromise at 7 days after the transplant. Our experimental model is technically feasible and reproducible and may provide important information about the pattern of rejection of cardiac and skeletal muscle allografts. © 1998 Wiley‐Liss, Inc. MICROSURGERY 18:406–409, 1998