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Free flap transplantation in mice
Author(s) -
Cooley Brian C.,
Daley Roger
Publication year - 1998
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/(sici)1098-2752(1998)18:5<320::aid-micr4>3.0.co;2-2
Subject(s) - medicine , anastomosis , groin , replantation , microsurgery , transplantation , microvascular surgery , surgery , femoral artery , free flap
A new model is presented that adapts the standard experimental groin free flap model to the mouse. The femoral vessels upon which the microvascular anastomoses are based are very small (0.2–0.4 mm diameter in the artery), making this a technically challenging exercise. A 100% patency was achieved for flap replantation in ICR (outbred) mice. Success rates for flap transplantation in Balb/ C (syngeneic) mice rose from 20 to 75% with modification of the anastomoses from end‐to‐end to end‐to‐side procedures. This model offers new avenues of investigation when combined with recently developed transgenic mouse models. © 1998 Wiley‐Liss, Inc. MICROSURGERY 18:320–323, 1998