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Reduction of reperfusion injury edema with corticotropin‐releasing factor (CRF): A pilot study
Author(s) -
Whitney Timothy M.,
Bentz Michael L.,
Johnson Peter C.
Publication year - 1998
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/(sici)1098-2752(1998)18:2<76::aid-micr3>3.0.co;2-s
Subject(s) - medicine , vascular permeability , endocrinology , edema , peripheral , hindlimb , reperfusion injury , anesthesia , ischemia
Regulation of capillary permeability with ischemic reperfusion injury is a complex interaction between vascular endothelium and circulating blood factors. Corticotropin‐releasing factor (CRF), a 41‐amino acid peptide CNS neurotransmitter known to modulate the pituitary–adrenal axis during stress response, has been shown to affect capillary leakage after thermal injury in peripheral tissue. When administered prior to ischemic reperfusion injury in a pedicled rat hindlimb model, CRF (80 mcg/kg) reduced limb weight gain to approximately 50% of saline control, suggesting a role for CRF in control of vascular permeability. The characteristics of CRF are reviewed. © 1998 Wiley‐Liss, Inc. MICROSURGERY 18:76‐78 1998