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Analysis of the retinoic acid receptor α gene as a candidate for the pulmonary adenoma resistance 1 gene
Author(s) -
Gariboldi Manuela,
Vivat Valerie,
De Gregorio Laura,
Manenti Giacomo,
Chiariello Elena,
Falvella F. Stefania,
Pierotti Marco A.,
Dragani Tommaso A.
Publication year - 1998
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/(sici)1098-2744(199801)21:1<13::aid-mc3>3.0.co;2-q
Subject(s) - biology , locus (genetics) , loss of heterozygosity , candidate gene , gene , genetics , microbiology and biotechnology , retinoic acid receptor , allele , retinoic acid , retinoic acid receptor alpha , retinoic acid receptor beta
The retinoic acid receptor α ( Rara ) gene, which maps in the same region as the pulmonary adenoma resistance ( Par1 ) locus on mouse chromosome 11 (Manenti G et al., Nature Genet 12:455–457, 1996), was tested as a candidate gene for Par1 . We report here the analysis of loss of heterozygosity, nucleotide sequence comparison, gene expression, and biochemical activity of the Rara gene from the Mus spretus ( Par1/ +) and A/J ( Par1/– ) mouse strains. The two Rara alleles were distinguished by two amino‐acid variations but had similar biochemical activity and expression levels, leading to the exclusion of Rara as a candidate Par1 gene. Mol. Carcinog. 21:13–16, 1998. © 1998 Wiley‐Liss, Inc.