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Matrilysin gene expression in sporadic and familial colorectal adenomas
Author(s) -
Takeuchi Nobumichi,
Ichikawa Yasushi,
Ishikawa Takashi,
Momiyama Nobuyoshi,
Hasegawa Satoshi,
Nagashima Yoji,
Miyazaki Kaoru,
Koshikawa Naohiko,
Mitsuhashi Masato,
Shimada Hiroshi
Publication year - 1997
Publication title -
molecular carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.254
H-Index - 97
eISSN - 1098-2744
pISSN - 0899-1987
DOI - 10.1002/(sici)1098-2744(199708)19:4<225::aid-mc2>3.0.co;2-b
Subject(s) - biology , matrilysin , gene , expression (computer science) , genetics , cancer research , matrix metalloproteinase , computer science , programming language
We examined the expression of matrilysin mRNA in sporadic and hereditary colorectal adenomas to clarify the role of matrilysin in tumorigenesis. Matrilysin mRNA was not detected in normal colorectal mucosa from patients with either sporadic or familial adenomas. Matrilysin mRNA expression in sporadic adenomas correlated with the degree of dysplasia and the size of the mass, whereas most of the adenomas in patients with familial adenomatous polyposis coli expressed matrilysin mRNA irrespective of adenoma size or degree of dysplasia. Because matrilysin is more likely to be expressed in adenomas with a potential for malignancy, this enzyme may play a role in the malignant conversion of colorectal adenomas. Mol. Carcinog. 19:225–229, 1997. © 1997 Wiley‐Liss, Inc.