Premium
Estrogen suppresses gastric motility response to thyrotropin‐releasing hormone and stress in awake rats
Author(s) -
Bond Eleanor F.,
Heitkemper Margaret M.,
Bailey Sandra L.
Publication year - 1998
Publication title -
research in nursing and health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.836
H-Index - 85
eISSN - 1098-240X
pISSN - 0160-6891
DOI - 10.1002/(sici)1098-240x(199806)21:3<221::aid-nur5>3.0.co;2-j
Subject(s) - medicine , endocrinology , estrogen , thyrotropin releasing hormone , ovariectomized rat , hormone , motility , neuropeptide , biology , receptor , genetics
Symptoms associated with gastric motility alteration vary with stress and ovarian hormone status, most notably in women with irritable bowel syndrome. This study examines combined effects, comparing gastric motility during administration of a stress‐related neuropeptide thyrotropin‐releasing hormone (TRH) and restraint stress in conscious rats of varied ovarian hormone status. Adult rats were ovariectomized and implanted with estrogen, progesterone, or vehicle‐releasing pellets. After 21 days, intracerebroventricular (I.C.) cannula and gastric tension transducer were implanted. After 25–27 days, motility was recorded during neuropeptide injection (TRH/saline I.C.) or restraint stress. TRH induced increased motility in all groups; the response varied with hormone group, and was least and briefest in estrogen‐treated rats. Motility during restraint varied with hormone group; it was diminished in estrogen‐treated but not other groups. Ovarian hormone status (estrogen) modifies gut response to TRH and restraint stress. © 1998 John Wiley & Sons, Inc. Res Nurs Health 21:221–228, 1998