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Short‐term regulation of energy intake is intact in hypophagic tumor‐bearing rats
Author(s) -
McCarthy Donna O.
Publication year - 1997
Publication title -
research in nursing and health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.836
H-Index - 85
eISSN - 1098-240X
pISSN - 0160-6891
DOI - 10.1002/(sici)1098-240x(199710)20:5<425::aid-nur6>3.0.co;2-q
Subject(s) - anorexia , food intake , medicine , endocrinology , body weight , physiology
Anorexia and weight loss are major problems in the care of cancer patients. Data from laboratory studies using an animal model of tumor‐induced anorexia suggest that energy intake may be regulated in the tumor‐bearing host as it is in healthy animals. The purpose of the pres‐ent study was to determine if hypophagic tumor‐bearing rats would alter their food intake in response to manipulations known to affect food intake in normal healthy animals. Both tumor‐bearing and healthy animals increased their food intake when housed at 22 versus 258° C and reduced their food intake when injected with anorexigenic doses of bacterial lipopolysaccharide or interleukin‐1 alpha. These data suggest that selected physiological responses affecting short‐term food intake are intact in the hypophagic tumor bearing host. © 1997 John Wiley & Sons, Inc. Res Nurs Health 20: 425–429, 1997