Premium
Repeated administration of methamphetamine damages cells in the somatosensory cortex: Overlap with cytochrome oxidase‐rich barrels
Author(s) -
O'Dell Steven J.,
Marshall John F.
Publication year - 2000
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/(sici)1098-2396(200007)37:1<32::aid-syn4>3.0.co;2-x
Subject(s) - cytochrome c oxidase , somatosensory system , methamphetamine , chemistry , cortex (anatomy) , neuroscience , anatomy , biophysics , biology , mitochondrion , pharmacology , biochemistry
Multiple injections of methamphetamine (mAMPH) cause degeneration of neurons in rat primary somatosensory cortex (Par1). These degenerating cells can be labeled histochemically with the fluorochrome dye, Fluoro‐Jade (FJ). This area of Par1 also contains the representation of the mystacial vibrissae. Neurons in this area of Par1 receiving projections derived from the vibrissae are arranged in discrete functional units (“barrels”), which are revealed by cytochrome oxidase (CO) histochemistry. Here, rats given mAMPH (four injections of 4 mg/kg, sc, 2‐h intervals between injections) showed FJ‐positive neurons in Par1 that were located predominantly near the perimeter of the CO‐dense barrels. Thus, the Par1 neurons damaged by multiple administration of mAMPH are located within whisker barrels. Synapse 37:32–37, 2000. © 2000 Wiley‐Liss, Inc.