Premium
Striatal dopamine receptors and transporters in monkeys with neonatal temporal limbic damage
Author(s) -
Heinz Andreas,
Saunders Richard C.,
Kolachana Bhaskar S.,
Jones Douglas W.,
Gorey Julia G.,
Bachevalier Jocelyne,
Weinberger Daniel R.
Publication year - 1999
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/(sici)1098-2396(199905)32:2<71::aid-syn1>3.0.co;2-q
Subject(s) - neuroscience , dopamine , dopamine transporter , dopamine receptor , receptor , limbic system , psychology , medicine , dopaminergic , central nervous system
Developmental cortical damage has been implicated in the basic neurobiology of schizophrenia. Adult rhesus monkeys with neonatal temporal limbic damage show a stimulus‐dependent disinhibition of subcortical dopamine (DA) release. We measured dopamine D2 receptors and transporters in vivo in rhesus monkeys with neonatal and adult mesial temporal limbic lesions and control monkeys to explore further the effects of this developmental lesion on striatal DA function. All monkeys were studied with [I‐123]IBZM SPECT to assess the availability of striatal dopamine D2 receptors and with [I‐123]β‐CIT SPECT to measure the availability of dopamine transporters in the striatum. IBZM binding was significantly reduced in monkeys with neonatal limbic lesions. No group difference in β‐CIT binding was found. The reduction in IBZM binding was significantly correlated with subcortical dopamine release after monoaminergic prefrontal stimulation as determinated with in vivo microdialysis. Our findings imply specific interactions between age at lesion and the availability of DA transporter and receptors in non‐human primates, and suggest that stimulus‐dependent DA activity affects the expression of DA receptors. Synapse 31:71–79, 1999. Published 1999 Wiley‐Liss, Inc.