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Maternal deprivation of neonatal rats produces enduring changes in dopamine function
Author(s) -
Hall F.S.,
Wilkinson L.S.,
Humby T.,
Robbins T.W.
Publication year - 1999
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/(sici)1098-2396(199904)32:1<37::aid-syn5>3.0.co;2-4
Subject(s) - neurochemical , dopamine , nucleus accumbens , dopaminergic , amphetamine , microdialysis , weanling , maternal deprivation , endocrinology , neuroscience , medicine , neurotransmitter , 3,4 dihydroxyphenylacetic acid , psychology , homovanillic acid , central nervous system , serotonin , receptor
Isolation‐rearing of weanling rats produces a syndrome of behavioral and neurochemical effects that are indicative of enhanced ventrostriatal dopamine function observed in adulthood. By contrast, maternal deprivation of neonatal rats decreases behavioral responses to dopamine agonists when tested in adults, which may indicate the opposite situation. However, in the present study it is reported that in vivo microdialysis of the nucleus accumbens (NAC) revealed enhanced release of dopamine (DA) in response to both d‐amphetamine and high K+ perfusate in maternally deprived subjects. Thus, behavioral responses to d‐amphetamine are diminished in maternally deprived rats despite apparent increases in presynaptic dopaminergic function in the NAC. Synapse 32:37–43, 1999. © 1999 Wiley‐Liss, Inc.