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Characterizing cortical neuron injury with fluoro‐jade labeling after a neurotoxic regimen of methamphetamine
Author(s) -
Eisch Amelia J.,
Schmued Larry C.,
Marshall John F.
Publication year - 1998
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/(sici)1098-2396(199811)30:3<329::aid-syn10>3.0.co;2-v
Subject(s) - methamphetamine , tyrosine hydroxylase , saline , neuron , neuroscience , cortex (anatomy) , posterior parietal cortex , chemistry , biology , pharmacology , dopamine , endocrinology
We used Fluoro‐Jade, a recently‐developed fluorescent indicator of neuronal damage, to identify neurons injured 1–21 days after repeated injections of methamphetamine (m‐AMPH) or saline. The m‐AMPH‐treated rats showed Fluoro‐Jade positive neurons in parietal cortex (layers III and IV) and had less striatal tyrosine hydroxylase immunoreactivity than did saline‐injected controls. Fluoro‐Jade positive neurons were greatest in number 3 days post‐treatment; some fluorescent neurons displayed bud‐like surface protrusions. These observations support the hypothesis that certain neocortical neurons degenerate after m‐AMPH. Synapse 30:329–333, 1998. © 1998 Wiley‐Liss, Inc.