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Age‐dependent decline of dopamine D1 receptors in human brain: A PET study
Author(s) -
Wang Yue,
Chan Grace L.Y.,
Holden James E.,
Dobko Teresa,
Mak Edwin,
Schulzer Michael,
Huser Joseph M.,
Snow Barry J.,
Ruth Thomas J.,
Calne Donald B.,
Stoessl A. Jon
Publication year - 1998
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/(sici)1098-2396(199809)30:1<56::aid-syn7>3.0.co;2-j
Subject(s) - putamen , dopamine , dopamine receptor , dopamine receptor d1 , dopaminergic , radioligand , medicine , receptor , endocrinology , dopamine receptor d2 , psychology , neuroscience
Radioligand binding studies in animals have demonstrated age‐related loss of dopamine receptors in the caudate and putamen. In humans, while age‐related declines in dopamine D2 receptors have been consistently reported, the effects of ageing on D1 receptors have been controversial. We used positron emission tomography (PET) with [ 11 C]SCH 23390 to investigate dopamine D1 receptor binding in 21 normal volunteers aged 22–74 years. We also assessed their motor function with a Modified Columbia Score (MCS) and the Purdue Pegboard Test (PPBT). D1 binding potentials were derived using a graphical analysis with a cerebellar tissue input function. Standard linear regression techniques were used to determine the age‐related rate of decline of D1 binding. We found an age‐dependent decrease of D1 receptor binding in the caudate (6.9% per decade) and putamen (7.4% per decade). There was also a significant inverse correlation between [ 11 C]SCH 23390 binding in the occipital cortex and age (8.6% decline per decade). PPBT score also decreased with age ( P = 0.007). There was a direct correlation between PPBT score and D1 binding potential. We conclude that dopamine D1 receptor density declines with age and that the effects of physiological ageing may play a role in the expression of extrapyramidal disorders in the elderly. Synapse 30:56–61, 1998. Published 1998 Wiley‐Liss, Inc.