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Serotonin 5‐HT 2A receptors are expressed on pyramidal cells and interneurons in the rat cortex
Author(s) -
Willins David L.,
Deutch Ariel Y.,
Roth Bryan L.
Publication year - 1997
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/(sici)1098-2396(199709)27:1<79::aid-syn8>3.0.co;2-a
Subject(s) - parvalbumin , serotonin , cortex (anatomy) , neuroscience , receptor , monoclonal antibody , cerebral cortex , antibody , biology , confocal , 5 ht receptor , chemistry , immunology , biochemistry , physics , optics
The distribution of 5‐HT 2A receptors in rat cortex was evaluated using newly developed antibodies. Each of three antibodies tested identified an identical pattern of 5‐HT 2A ‐like immunoreactivity (5‐HT 2A ‐li) in rat cortex with 5‐HT 2A ‐li showing a widespread distribution. The majority of 5‐HT 2A ‐li cells displayed a pyramidal morphology. While a minority, some cortical neurons with a bipolar morphology displayed 5‐HT 2A ‐li as well. Dual‐label fluorescence confocal microscopic studies with a 5‐HT 2A antibody and a mouse monoclonal antibody to parvalbumin, a marker of a subset of gamma aminobutyric acid (GABA)ergic interneurons in the cortex, demonstrated that although some cells expressing 5‐HT 2A ‐li were interneurons, most were not. Synapse 27:79–82, 1997. © 1997 Wiley‐Liss, Inc.