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Long‐lasting decreases of AMPA responses following postsynaptic activity in single hippocampal neurons
Author(s) -
Vickery Richard M.,
Bindman Lynn J.
Publication year - 1997
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/(sici)1098-2396(199701)25:1<103::aid-syn12>3.0.co;2-0
Subject(s) - ampa receptor , postsynaptic potential , neuroscience , excitatory postsynaptic potential , long term potentiation , synapse , silent synapse , chemistry , stimulation , postsynaptic current , biology , inhibitory postsynaptic potential , glutamate receptor , receptor , biochemistry
Direct postsynaptic depolarization and firing of single CA1 neurons caused decreased responses to iontophoresed α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole propionic acid (AMPA). Since there was no associated change in the excitatory postsynaptic potential (EPSP) evoked by electrical stimulation in the same band of stratum radiatum, we infer that the decreased AMPA response was mediated predominantly by extra‐synaptic receptors. The decreased AMPA response developed within 10–30 min after conditioning, a time course similar to the delayed increase in AMPA responses associated with long‐term potentiation (LTP) [Davies et al. (1989), Nature, 338:500–503; Sergueeva et al. (1993), Neuropharmacology, 32:933–935]. Our observations suggest the existence of mirror‐image processes that may regulate AMPA receptors and possibly synaptic efficacy. Synapse 25:103–106, 1997. © 1997 Wiley‐Liss, Inc.