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C‐Fos expression as a molecular marker in corticotropin‐releasing factor‐induced seizures
Author(s) -
Marrosu Francesco,
Pinna Annalisa,
Fadda Paola,
Fratta Walter,
Morelli Micaela
Publication year - 1996
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/(sici)1098-2396(199611)24:3<297::aid-syn12>3.0.co;2-u
Subject(s) - hippocampal formation , neuroscience , electroencephalography , epilepsy , neuropeptide , hippocampus , c fos , amygdala , premovement neuronal activity , psychology , endocrinology , medicine , chemistry , biology , gene expression , receptor , biochemistry , gene
Expression of Fos‐like protein has been shown to increase after seizures in several types of experimentally induced epilepsies. The intracerebroventricular (icv) injection of murine corticotropin‐releasing factor (CRF) in rats (10 μg), shows an electroencephalographic (EEG) spiking activity restricted to the amygdaloid‐hippocampal area. This EEG seizure pattern represents a unique model of localized epileptic activity induced by a neuropeptide. C‐fos expression after icv CRF has been considered a useful tool in mapping areas involved in stress and in seizure activity. Our results show that 1 μg and 10 μg CRF are able to induce c‐fos activation in several brain areas. Moreover, the present study not only details c‐fos expression increase in brain areas directly involved in spiking activation, such as the amygdaloid‐hippocampal region, but also maps the possible contribution of other regions to seizure manifestations. © 1996 Wiley‐Liss, Inc.