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Distribution of dopamine D1‐D4 receptor subtypes in human dorsal vagal complex
Author(s) -
Hyde Thomas M.,
Knable Michael B.,
Murray Angela M.
Publication year - 1996
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/(sici)1098-2396(199611)24:3<224::aid-syn4>3.0.co;2-g
Subject(s) - area postrema , dorsal motor nucleus , solitary tract , receptor , neuroscience , biology , medulla , nucleus , vagus nerve , dopamine receptor d2 , dopamine , anatomy , stimulation , biochemistry
Abstract The distribution of D1/D5, D2/D3, D2/D3/D4, and individually, putative D2‐D4 receptors across the dorsal vagal complex of the human medulla was assessed with quantitative receptor autoradiography. D1/D5 receptors were found in very low levels. D2 receptors were concentrated in the intermediate and medial subnuclei of the nucleus of the solitary tract (NTS), and in the dorsal motor nucleus of the vagus (DMN), while D3 receptors were more homogenous across the entire NTS, area postrema (AP), and DMN. In contrast, D4 receptors were found almost exclusively in the intermediate and medial subnuclei of the NTS, and in the DMN. These findings suggest that the “D2 family” of receptors is an important component of brain stem mechanisms regulating visceral function, including gastrointestinal systems, such as emesis, along with cardiovascular and pulmonary systems. Compounds with individual selectivity for D2, D3, or D4 receptors may be useful in the manipulation of neural networks regulating these visceral systems. © 1996 Wiley‐Liss, Inc. This article is a US Government work and, as such, is in the public domain in the United States of America.