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Striatal c‐fos levels do not correlate with haloperidol‐induced behavioral supersensitivity
Author(s) -
Marin Concepció,
Bonastre Mercè,
Tolosa Eduardo
Publication year - 1996
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/(sici)1098-2396(199606)23:2<89::aid-syn4>3.0.co;2-c
Subject(s) - quinpirole , haloperidol , apomorphine , agonist , stereotypy , dopamine agonist , chemistry , endocrinology , pharmacology , medicine , striatum , dopamine , receptor , amphetamine
Striatal c‐fos levels and stereotyped behavior have been evaluated in chronically haloperidol‐treated rats which received subsequent subacute dopamine (DA) agonist treatment to investigate the possible relationship between striatal c‐fos and behavioral supersensitivity. Haloperidol treatment (1 mg/kg/day for 21 days) increased apomorphine‐induced stereotypies but did not modify striatal c‐fos levels. The subacute administration of the DA D‐1 agonist SKF38393 (10 mg/kg/day for 5 days) and the combination of the D‐1 agonist with the D‐2 agonist quinpirole (1 mg/kg/day for 5 days) attenuated apomorphine‐induced stereotypies after haloperidol pretreatment. The administration of quinpirole alone, however, did not modify the response to haloperidol. All DA agonists significantly increased c‐fos levels after apomorphine injection. The dissociation between haloperidol‐induced behavioral supersensitivity and striatal c‐fos levels observed in this study suggests that mechanisms different from striatal c‐fos induction might be involved, and that striatal c‐fos levels are not a good marker of behavioral supersensitivity expression. © 1996 Wiley‐Liss, Inc.