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Secretory patterns of serum prolactin in Asian ( Elephas maximus ) and African ( Loxodonta africana ) elephants during different reproductive states: Comparison with concentrations in a noncycling African elephant
Author(s) -
Brown Janine L.,
Lehnhardt John
Publication year - 1997
Publication title -
zoo biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.5
H-Index - 54
eISSN - 1098-2361
pISSN - 0733-3188
DOI - 10.1002/(sici)1098-2361(1997)16:2<149::aid-zoo5>3.0.co;2-a
Subject(s) - elephas , prolactin , african elephant , biology , estrous cycle , endocrinology , medicine , luteinizing hormone , asian elephant , anovulation , hormone , ecology , obesity , insulin resistance , polycystic ovary
Serum prolactin was quantified in adult female Asian ( Elephas maximus ) and African ( Loxodonta africana ) elephants during various reproductive states and the profiles compared to that in a noncycling African elephant. In reproductively normal elephants, there was no effect of season, estrous cycle stage, or lactational status on quantitative or qualitative prolactin secretion ( P > 0.05), nor where there any differences ( P > 0.05) in overall prolactin concentrations between species. In pregnant elephants, prolactin concentrations remained at baseline for the first 4–6 months of gestation. Thereafter, concentrations during early pregnancy averaged ∼four‐fold higher than those during the estrous cycle, increasing to ∼100‐fold over baseline during mid‐ to late gestation in both species. In contrast to cycling elephants, prolactin concentrations in an African elephant exhibiting chronic anovulation (on the basis of an acyclic serum progesterone profile) and mild galactorrhea were consistently about five‐fold higher ( P < 0.05), suggesting she is hyperprolactinemic. Other endocrinological assesments confirmed the hypogonadal state of this female. Serum estradiol concentrations were consistently at or below detectable levels. Additionally, no preovulatory luteinizing hormone (LH) surges occurred in daily serum samples analyzed over a 12‐month period. The pituitary was not totally refractory, however, and responded with a several‐fold increase in serum LH concentration (peak, 3.07 ng/ml) over baseline (0.75 ng/ml) after i.v. injection of gonadotropin‐releasing hormone. This study describes normal baseline serum prolactin values for Asian and African elephants and is the first to identify hyperprolactinemia as a possible cause of reproductive acyclicity and galactorrhea in an African elephant. Zoo Biol 16:149–159, 1997. © 1997 Wiley‐Liss, Inc.