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Teratoma with trisomy 16 in a baboon ( Papio hamadryas )
Author(s) -
Moore Charleen M.,
McKeand Jennifer,
Witte Shelly M.,
Hubbard Gene B.,
Rogers Jeffrey,
Leland M. Michelle
Publication year - 1998
Publication title -
american journal of primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 81
eISSN - 1098-2345
pISSN - 0275-2565
DOI - 10.1002/(sici)1098-2345(1998)46:4<323::aid-ajp4>3.0.co;2-b
Subject(s) - baboon , biology , trisomy , teratoma , chromosome , genetics , pathology , medicine , endocrinology , gene
A teratoma was found during a planned cesarean section in a 10‐year‐old primigravida baboon. This teratoma had a female sex chromosome complement and trisomy for chromosome 16. This is the first report of a teratoma in a baboon and the first report of a chromosomal abnormality in a nonhuman primate teratoma. It is also the first case in a nonhuman primate to address the mechanism of origin. Through the use of genetic markers from human chromosomes 5, 8 and 17, the origin of the teratoma was shown to be most consistent with failure of meiosis II or endoreduplication in a mature ovum, while the trisomy for chromosome 16 originated after the formation of the tumor. Am. J. Primatol. 46:323–332, 1998. © 1998 Wiley‐Liss, Inc.