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Oral 18 F‐fluoro‐2‐deoxyglucose for primate PET studies without behavioral restraint: Demonstration of principle
Author(s) -
Martinez Zoe Allen,
Colgan Mark,
Baxter Lewis R.,
Quintana Javier,
Siegel Stefan,
Chatziioannou Arion,
Cherry Simon R.,
Mazziotta John C.,
Phelps Michael E.
Publication year - 1997
Publication title -
american journal of primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 81
eISSN - 1098-2345
pISSN - 0275-2565
DOI - 10.1002/(sici)1098-2345(1997)42:3<215::aid-ajp4>3.0.co;2-#
Subject(s) - deoxyglucose , positron emission tomography , nuclear medicine , positron , primate , medicine , oral administration , psychology , physics , endocrinology , neuroscience , quantum mechanics , electron
We describe a method of orally administering 18 F‐fluoro‐2‐deoxyglucose (FDG) for positron emission tomography (PET) scans to determine local cerebral metabolic rates for glucose (LCMRGlc), normalized to that of whole brain, in fully conscious, non‐restrained primates. Oral FDG‐PET studies were performed in both non‐restrained and chaired monkeys, and in one human where results could be compared with traditional intravenous FDG administration. The oral route of FDG administration gave images and whole brain‐normalized PET LCMRGlc results comparable to those obtained by the intravenous route. This oral FDG‐PET method may provide a useful means by which to obtain measures of LCMRGlcs for brain structures, relative to each other, in non‐restrained, non‐druggd primates in field and laboratory studies. This method might also have clinical applications for PET studies of children. Am. J. Primatol. 42:215–224, 1997. © 1997 Wiley‐Liss, Inc.