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Cardiac electrophysiological actions of adenosine
Author(s) -
Srinivas Miduturu,
Song Yejia,
Shryock John C.,
Belardinelli Luiz
Publication year - 1998
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/(sici)1098-2299(199811/12)45:3/4<420::aid-ddr43>3.0.co;2-y
Subject(s) - adenosine , electrophysiology , nucleoside , stimulation , adenosine receptor , chemistry , receptor , medicine , adenosine a1 receptor , inhibitory postsynaptic potential , neuroscience , endocrinology , biology , agonist , biochemistry
Adenosine, an endogenous nucleoside, modulates heart functions via cell membrane receptors. This review focuses on the A 1 adenosine receptor‐mediated electrophysiological effects on cardiac myocytes. Activation of A 1 adenosine receptors leads to reductions of heart rate, atrioventricular nodal conduction, and atrial contractile force, and to an attenuation of the effects of β‐adrenergic stimulation on myocardium. The ionic mechanisms and the receptor‐effector coupling systems that underly the inhibitory effects of adenosine are discussed. Drug Dev. Res. 45:420–426, 1998. © 1998 Wiley‐Liss, Inc.