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Hypolipidaemic activity of dimethoxy unconjugated propenyl side‐chain analogs of α‐asarone in mice
Author(s) -
Chamorro Germán,
Garduño Leticia,
Sánchez Adrián,
Labarrios Fernando,
Salazar María,
Martínez Elizdath,
Díaz Francisco,
Tamariz Joaquín
Publication year - 1998
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/(sici)1098-2299(199802)43:2<105::aid-ddr3>3.0.co;2-o
Subject(s) - chemistry , propenyl , cholesterol , pharmacology , oral administration , blood lipids , lipoprotein , side chain , biochemistry , medicine , organic chemistry , polymer
The hypolipidaemic activity of several dimethoxy unconjugated propenyl side‐chain analogs of α‐asarone were investigated in hyperlipidaemic mice after six days of treatment. Eugenol and the α‐asarone analog with amino groups on the C‐4 position of the aromatic ring were observed to be the most effective hypolipidaemic agents at the dose of 80 mg/kg/day p.o. These compounds significantly lowered total serum cholesterol, low density lipoprotein (LDL‐cholesterol), and triglycerides content. On the other hand, high density lipoprotein (HDL‐cholesterol) was increased by administration of these hypolipidaemic agents. The ability to modulate the levels of these lipids suggests that these agents could be effective in the treatment of hyperlipidaemic states. These compounds appeared to be safe when administered at an oral dose of 80 mg/kg/day, which is within the therapeutic range in mice. Drug Dev. Res. 43:105–108, 1998. © 1998 Wiley‐Liss, Inc.