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“Hinge” peptide libraries in basic research and drug development: Application to breast cancer and multiple sclerosis
Author(s) -
Moore Graham J.
Publication year - 1997
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/(sici)1098-2299(199711/12)42:3/4<157::aid-ddr7>3.0.co;2-p
Subject(s) - linker , multiple sclerosis , peptide , drug , drug discovery , breast cancer , peptide library , computational biology , chemistry , cancer research , combinatorial chemistry , cancer , medicine , peptide sequence , pharmacology , biochemistry , biology , computer science , immunology , gene , operating system
Libraries of peptides in which a centrally located linker group is introduced to deliberately disrupt the ordered backbone structure and allow the flanking amino acid sidechains to cluster together are called “hinge” or “hairpin” peptide libraries. Screening of these libraries with bioassays directed towards breast cancer and multiple sclerosis has yielded promising new leads in the search for novel therapeutic entities to treat these diseases. Drug Dev. Res. 42:157–163, 1997. © 1997 Wiley‐Liss, Inc.