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Antagonist binding sites of voltage‐dependent calcium channels
Author(s) -
Zamponi Gerald W.
Publication year - 1997
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/(sici)1098-2299(199711/12)42:3/4<131::aid-ddr4>3.0.co;2-r
Subject(s) - calcium channel , n type calcium channel , r type calcium channel , antagonist , voltage dependent calcium channel , calcium , chemistry , t type calcium channel , p type calcium channel , pharmacology , peptide , biophysics , biology , receptor , biochemistry , organic chemistry
Voltage‐dependent calcium channels are crucial targets for a wide range of clinically active small organic pharmacological agents. These agents fall into several distinct classes of blockers, each associated with a unique site on the calcium channel α 1 subunit. In addition, a number of peptide toxins isolated from invertebrates specifically bind to and block certain subtypes of voltage‐dependent calcium channels. Voltage‐dependent calcium channels are comprised of multiple subtypes, and not each of those subtypes are equally sensitive to small organic compounds and peptide blockers. Here, I present an overview of the classes of calcium channel blockers and our current understanding of their sites of action on the calcium channel protein. Drug Dev. Res. 42:131–143, 1997. © 1997 Wiley‐Liss, Inc.