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Electrophysiological effects of Gallanilide on cardiac ventricular and Purkinje fibers
Author(s) -
ShangZhong Xu,
XinYing Zhu,
ShouQi Yan
Publication year - 1997
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/(sici)1098-2299(199701)40:1<94::aid-ddr10>3.0.co;2-h
Subject(s) - purkinje fibers , electrophysiology , effective refractory period , refractory period , papillary muscle , guinea pig , medicine , cardiology , chemistry
The effects of gallanilide on action potentials were studied in swine ventricular muscles, Purkinje fibers, and guinea pig papillary muscles by conventional microelectrode techniques. Gallanilide (1–10 μM) prolonged the action potential duration (APD) and effective refractory period (ERP) in ventricular muscles and Purkinje fibers. The ratio of ERP/APD 90 increased. The slopes of phase 1 and phase 3 of action potential were flattened. Gallanilide (10 μM) decreased the maximal rising rate and amplitude of the action potential. The depressant effect on the maximal rising rate was frequency‐dependent. These results suggest that gallanilide possesses both class I and III antiarrhythmic actions, which may be the electrophysiological basis of its antiarrhythmic effect. Drug Dev. Res. 40:94–98, 1997. © 1997 Wiley‐Liss, Inc.