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Anti‐inflammatory effects of adenosine kinase inhibitors in acute and chronic inflammation
Author(s) -
Firestein Gary S.
Publication year - 1996
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/(sici)1098-2299(199611/12)39:3/4<371::aid-ddr18>3.0.co;2-4
Subject(s) - adenosine , adenosine kinase , pharmacology , inflammation , medicine , adenosine a2a receptor , rheumatoid arthritis , adenosine a3 receptor , arthritis , carrageenan , adenosine receptor , immunology , receptor , agonist , adenosine deaminase
Adenosine (Ado) exhibits a variety of anti‐inflammatory activities, including inhibition of neutrophil oxygen radical production, adhesion to vascular endothelium and macrophage TNF‐alpha gene expression. The therapeutic uses of Ado and its analogues, however, are limited by severe side effects like hypotension and bradycardia. Therefore, adenosine regulating agents with site and event specificity have been developed to enhance endogenous adenosine production. Adenosine kinase inhibitors were especially active anti‐inflammatory agents and demonstrated efficacy in several models, including carrageenan paw edema, carrageenan air pouch, and adjuvant arthritis in rats. These studies suggest that adenosine kinase inhibitors have potential utility in diseases like rheumatoid arthritis. Drug Dev. Res. 39:371–376, 1996. © 1997 Wiley‐Liss, Inc.