Premium
Adenosine receptors involved in the bronchoconstrictor effect of adenosine
Author(s) -
Joos Guy F.,
Pauwels Romain A.
Publication year - 1996
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/(sici)1098-2299(199611/12)39:3/4<330::aid-ddr13>3.0.co;2-5
Subject(s) - adenosine , adenosine receptor , bronchoconstriction , receptor , pharmacology , adenosine a3 receptor , purinergic signalling , adenosine a1 receptor , chemistry , medicine , endocrinology , agonist , asthma
Adenosine may play a role in the airflow obstruction in asthma and chronic obstructive pulmonary disease. Although the mechanism of adenosine‐induced bronchoconstriction has been well explored, little is known about the identity of adenosine‐receptors involved. Studies on rabbit and rat airways suggest that multiple receptors (A 1 , A 2B , and A 3 receptors) may be involved in the bronchoconstrictor of adenosine. Mast cell mediators contribute to adenosine‐induced bronchoconstriction. Studies on isolated mast cell lines have revealed the presence of A 2B and A 3 receptors. The in vitro contraction of human bronchi is mediated by an adenosine receptor (A 1 or A 2 ?). A 2 receptors have been demonstrated by ligand binding in human peripheral airways. The presence of the A 3 receptor has been shown by in situ hybridization in eosinophils and mesenchymal tissue. The development of potent and specific adenosine receptor agonists and antagonists will increase our knowledge on this issue and may offer new therapeutic approaches to obstructive airway diseases. Drug Dev. Res. 39:330–332, 1996. © 1997 Wiley‐Liss, Inc.